{"id":419,"date":"2024-01-03T13:29:28","date_gmt":"2024-01-03T05:29:28","guid":{"rendered":"https:\/\/tcc.sg\/?page_id=419"},"modified":"2025-05-19T10:00:29","modified_gmt":"2025-05-19T02:00:29","slug":"genetic","status":"publish","type":"page","link":"https:\/\/tcc.sg\/vi\/services\/screening\/genetic\/","title":{"rendered":"Hi\u1ec3u V\u1ec1 Ung Th\u01b0 Di Truy\u1ec1n v\u00e0 X\u00e9t Nghi\u1ec7m BRCA t\u1ea1i Singapore"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"419\" class=\"elementor elementor-419\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-47e5f53 e-flex e-con-boxed e-con e-parent\" data-id=\"47e5f53\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-155e9d0 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"155e9d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Understanding Genetic Cancers and BRCA Testing in Singapore<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8ec7190 e-con-full e-flex e-con e-parent\" data-id=\"8ec7190\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-d518023 e-con-full e-flex e-con e-child\" data-id=\"d518023\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-dece67a e-flex e-con-boxed e-con e-child\" data-id=\"dece67a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-60ba64d e-con-full e-flex e-con e-child\" data-id=\"60ba64d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8609a27 elementor-widget__width-initial exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image\" data-id=\"8609a27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"500\" src=\"https:\/\/tcc.sg\/wp-content\/uploads\/2024\/01\/the-cancer-centre-genetic-screening.webp\" class=\"elementor-animation-float attachment-full size-full wp-image-553\" alt=\"Genetic Test (BRCA1 &amp; BRCA 2) For Cancer\" srcset=\"https:\/\/tcc.sg\/wp-content\/uploads\/2024\/01\/the-cancer-centre-genetic-screening.webp 800w, https:\/\/tcc.sg\/wp-content\/uploads\/2024\/01\/the-cancer-centre-genetic-screening-300x188.webp 300w, https:\/\/tcc.sg\/wp-content\/uploads\/2024\/01\/the-cancer-centre-genetic-screening-768x480.webp 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bf780cb e-con-full e-flex e-con e-child\" data-id=\"bf780cb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3d5619 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"f3d5619\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In 2013, Hollywood actress Angelina Jolie made headlines &#8211; not for a film, but for a deeply personal medical decision. After learning she carried a BRCA1 gene mutation, which significantly increases the risk of breast and ovarian cancer, she opted for a preventive double mastectomy and later had her ovaries removed. Her public disclosure sparked what is now known as \u201cThe Angelina Jolie Effect\u201d &#8211; a global surge in interest around genetic cancer testing and awareness of hereditary cancers.<\/p><p>Today, that effect still resonates, including here in Singapore, where more individuals are beginning to explore genetic screening as a way to understand their cancer risk and take proactive steps toward better health.<\/p><p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-341c9ef e-flex e-con-boxed e-con e-child\" data-id=\"341c9ef\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ec246a5 e-con-full e-flex e-con e-child\" data-id=\"ec246a5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b1f296d exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"b1f296d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">What Are Genetic Cancers?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e24e8c exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"3e24e8c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Genetic (or hereditary) cancers result from inherited gene mutations that increase an individual&#8217;s risk of developing certain types of cancer.<\/p><p>Common hereditary cancers include:<\/p><p><a href=\"https:\/\/tcc.sg\/vi\/services\/cancers-we-treat\/breast\/\">Breast cancer<\/a><br \/><a href=\"https:\/\/tcc.sg\/vi\/services\/cancers-we-treat\/ovarian\/\">Ovarian cancer<\/a><br \/><a href=\"https:\/\/tcc.sg\/vi\/services\/cancers-we-treat\/colorectal\/\">Colorectal cancer<\/a><br \/>Pancreatic cancer<br \/><a href=\"https:\/\/tcc.sg\/vi\/services\/cancers-we-treat\/prostate\/\">Prostate cancer<\/a><br \/>Melanoma<br \/>Retinoblastoma<br \/>Thyroid cancer<br \/><a href=\"https:\/\/tcc.sg\/vi\/services\/cancers-we-treat\/uterine\/\">Womb (endometrial) cancer<\/a><\/p><p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8c046c0 e-con-full e-flex e-con e-child\" data-id=\"8c046c0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-57d503c exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image\" data-id=\"57d503c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"527\" src=\"https:\/\/tcc.sg\/wp-content\/uploads\/2025\/04\/BRCA-Mutation-1024x674.jpg\" class=\"attachment-large size-large wp-image-4717\" alt=\"\" srcset=\"https:\/\/tcc.sg\/wp-content\/uploads\/2025\/04\/BRCA-Mutation-1024x674.jpg 1024w, https:\/\/tcc.sg\/wp-content\/uploads\/2025\/04\/BRCA-Mutation-300x198.jpg 300w, https:\/\/tcc.sg\/wp-content\/uploads\/2025\/04\/BRCA-Mutation-768x506.jpg 768w, https:\/\/tcc.sg\/wp-content\/uploads\/2025\/04\/BRCA-Mutation.jpg 1200w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3f5925c e-flex e-con-boxed e-con e-child\" data-id=\"3f5925c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-956b5df e-con-full e-flex e-con e-child\" data-id=\"956b5df\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-04f72d5 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"04f72d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>The Role of BRCA1 and BRCA2 Genes<br \/><\/strong><br \/>BRCA1 and BRCA2 are tumour suppressor genes that help repair DNA damage. Mutations in these genes can significantly increase cancer risk:<\/p><ul><li>Breast Cancer: Women with BRCA1\/2 mutations have a 49\u201357% lifetime risk, compared to 12% in the general population.<\/li><li>Ovarian Cancer: The risk rises to 18\u201340%, versus about 1% in those without the mutation. These mutations may also raise the risk for pancreatic and prostate cancers.<\/li><\/ul><p><strong><br \/>Who Should Consider BRCA Genetic Testing?<\/strong><\/p><p>BRCA genetic testing is especially recommended for individuals with: Multiple family members diagnosed with breast or ovarian cancer, particularly before age 50<\/p><ul><li>Male relatives with breast cancer<\/li><li>Relatives with bilateral breast cancer or both breast and ovarian cancers<\/li><li>Known BRCA1 or BRCA2 mutations in the family<\/li><\/ul><p><strong><br \/>Preventive Measures and Management<\/strong><\/p><p>For individuals who test BRCA-positive, several strategies can reduce cancer risk:<\/p><ul><li>Enhanced Surveillance: Regular screenings like mammograms and MRIs, beginning at a younger age<\/li><li>Preventive procedures such as bilateral prophylactic mastectomies and bilateral salpingo-oophorectomies (removal of the ovaries and fallopian tubes) can dramatically lower cancer risk<\/li><\/ul><p><br \/>However, it is essential to note that these decisions are best made in consultation with a specialist and tailored to the individual&#8217;s risk profile and personal circumstances.<\/p><p><strong><br \/>Conclusion<\/strong><\/p><p>Understanding hereditary cancer risks &#8211; especially BRCA-related mutations &#8211; is a vital step in proactive health planning. With established, trusted services like NCCS and others, Singaporeans can access the tools and support needed to make informed decisions and protect their long-term well-being.<\/p><p><strong><br \/>Sources<\/strong><br \/><a href=\"http:\/\/HealthXchange.sg\" target=\"_blank\" rel=\"noopener\">HealthXchange.sg \u2013 Genetic Testing: Who Should Get It?<\/a><br \/><a href=\"https:\/\/www.mountelizabeth.com.sg\/tests-treatments\/brca-genetic-testing\" target=\"_blank\" rel=\"noopener\">Mount Elizabeth Hospital \u2013 BRCA Genetic Testing<\/a><br \/><a href=\"https:\/\/www.nccs.com.sg\/patient-care\/specialties-services\/cancer-genetics-service\" target=\"_blank\" rel=\"noopener\">National Cancer Centre Singapore \u2013 Cancer Genetics Service<\/a><br \/><a href=\"https:\/\/time.com\/3450368\/the-angelina-effect\/\" target=\"_blank\" rel=\"noopener\">TIME \u2013 The Angelina Effect<\/a><\/p><p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Hi\u1ec3u V\u1ec1 Ung Th\u01b0 Di Truy\u1ec1n v\u00e0 X\u00e9t Nghi\u1ec7m BRCA t\u1ea1i Singapore N\u0103m 2013, n\u1eef di\u1ec5n vi\u00ean Hollywood Angelina Jolie \u0111\u00e3 g\u00e2y ch\u1ea5n \u0111\u1ed9ng d\u01b0 lu\u1eadn \u2014 kh\u00f4ng ph\u1ea3i v\u00ec m\u1ed9t b\u1ed9 phim, m\u00e0 b\u1edfi m\u1ed9t quy\u1ebft \u0111\u1ecbnh y t\u1ebf \u0111\u1ea7y t\u00ednh c\u00e1 nh\u00e2n. Sau khi bi\u1ebft m\u00ecnh mang \u0111\u1ed9t bi\u1ebfn gen BRCA1, l\u00e0m t\u0103ng [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":412,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-419","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Genetic (BRCA1&amp;2) Screening Test Singapore | The Cancer Centre<\/title>\n<meta name=\"description\" content=\"Genetic screening detects the hereditary cancer occurrence associated with the inherited gene (BRCA). 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