{"id":419,"date":"2024-01-03T13:29:28","date_gmt":"2024-01-03T05:29:28","guid":{"rendered":"https:\/\/tcc.sg\/?page_id=419"},"modified":"2025-05-19T10:00:29","modified_gmt":"2025-05-19T02:00:29","slug":"genetic","status":"publish","type":"page","link":"https:\/\/tcc.sg\/zh\/services\/screening\/genetic\/","title":{"rendered":"\u4e86\u89e3\u9057\u4f20\u6027\u764c\u75c7\u4e0eBRCA\u57fa\u56e0\u68c0\u6d4b\u5728\u65b0\u52a0\u5761\u7684\u5e94\u7528"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"419\" class=\"elementor elementor-419\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-47e5f53 e-flex e-con-boxed e-con e-parent\" data-id=\"47e5f53\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-155e9d0 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"155e9d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Understanding Genetic Cancers and BRCA Testing in Singapore<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8ec7190 e-con-full e-flex e-con e-parent\" data-id=\"8ec7190\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-d518023 e-con-full e-flex e-con e-child\" data-id=\"d518023\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-dece67a e-flex e-con-boxed e-con e-child\" data-id=\"dece67a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-60ba64d e-con-full e-flex e-con e-child\" data-id=\"60ba64d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8609a27 elementor-widget__width-initial exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image\" data-id=\"8609a27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"500\" src=\"https:\/\/tcc.sg\/wp-content\/uploads\/2024\/01\/the-cancer-centre-genetic-screening.webp\" class=\"elementor-animation-float attachment-full size-full wp-image-553\" alt=\"Genetic Test (BRCA1 &amp; BRCA 2) For Cancer\" srcset=\"https:\/\/tcc.sg\/wp-content\/uploads\/2024\/01\/the-cancer-centre-genetic-screening.webp 800w, https:\/\/tcc.sg\/wp-content\/uploads\/2024\/01\/the-cancer-centre-genetic-screening-300x188.webp 300w, https:\/\/tcc.sg\/wp-content\/uploads\/2024\/01\/the-cancer-centre-genetic-screening-768x480.webp 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bf780cb e-con-full e-flex e-con e-child\" data-id=\"bf780cb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3d5619 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"f3d5619\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In 2013, Hollywood actress Angelina Jolie made headlines &#8211; not for a film, but for a deeply personal medical decision. After learning she carried a BRCA1 gene mutation, which significantly increases the risk of breast and ovarian cancer, she opted for a preventive double mastectomy and later had her ovaries removed. Her public disclosure sparked what is now known as \u201cThe Angelina Jolie Effect\u201d &#8211; a global surge in interest around genetic cancer testing and awareness of hereditary cancers.<\/p><p>Today, that effect still resonates, including here in Singapore, where more individuals are beginning to explore genetic screening as a way to understand their cancer risk and take proactive steps toward better health.<\/p><p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-341c9ef e-flex e-con-boxed e-con e-child\" data-id=\"341c9ef\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ec246a5 e-con-full e-flex e-con e-child\" data-id=\"ec246a5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b1f296d exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"b1f296d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">What Are Genetic Cancers?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e24e8c exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"3e24e8c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Genetic (or hereditary) cancers result from inherited gene mutations that increase an individual&#8217;s risk of developing certain types of cancer.<\/p><p>Common hereditary cancers include:<\/p><p><a href=\"https:\/\/tcc.sg\/zh\/services\/cancers-we-treat\/breast\/\">Breast cancer<\/a><br \/><a href=\"https:\/\/tcc.sg\/zh\/services\/cancers-we-treat\/ovarian\/\">Ovarian cancer<\/a><br \/><a href=\"https:\/\/tcc.sg\/zh\/services\/cancers-we-treat\/colorectal\/\">Colorectal cancer<\/a><br \/>Pancreatic cancer<br \/><a href=\"https:\/\/tcc.sg\/zh\/services\/cancers-we-treat\/prostate\/\">Prostate cancer<\/a><br \/>Melanoma<br \/>Retinoblastoma<br \/>Thyroid cancer<br \/><a href=\"https:\/\/tcc.sg\/zh\/services\/cancers-we-treat\/uterine\/\">Womb (endometrial) cancer<\/a><\/p><p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8c046c0 e-con-full e-flex e-con e-child\" data-id=\"8c046c0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-57d503c exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image\" data-id=\"57d503c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"527\" src=\"https:\/\/tcc.sg\/wp-content\/uploads\/2025\/04\/BRCA-Mutation-1024x674.jpg\" class=\"attachment-large size-large wp-image-4717\" alt=\"\" srcset=\"https:\/\/tcc.sg\/wp-content\/uploads\/2025\/04\/BRCA-Mutation-1024x674.jpg 1024w, https:\/\/tcc.sg\/wp-content\/uploads\/2025\/04\/BRCA-Mutation-300x198.jpg 300w, https:\/\/tcc.sg\/wp-content\/uploads\/2025\/04\/BRCA-Mutation-768x506.jpg 768w, https:\/\/tcc.sg\/wp-content\/uploads\/2025\/04\/BRCA-Mutation.jpg 1200w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3f5925c e-flex e-con-boxed e-con e-child\" data-id=\"3f5925c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-956b5df e-con-full e-flex e-con e-child\" data-id=\"956b5df\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-04f72d5 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"04f72d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>The Role of BRCA1 and BRCA2 Genes<br \/><\/strong><br \/>BRCA1 and BRCA2 are tumour suppressor genes that help repair DNA damage. Mutations in these genes can significantly increase cancer risk:<\/p><ul><li>Breast Cancer: Women with BRCA1\/2 mutations have a 49\u201357% lifetime risk, compared to 12% in the general population.<\/li><li>Ovarian Cancer: The risk rises to 18\u201340%, versus about 1% in those without the mutation. These mutations may also raise the risk for pancreatic and prostate cancers.<\/li><\/ul><p><strong><br \/>Who Should Consider BRCA Genetic Testing?<\/strong><\/p><p>BRCA genetic testing is especially recommended for individuals with: Multiple family members diagnosed with breast or ovarian cancer, particularly before age 50<\/p><ul><li>Male relatives with breast cancer<\/li><li>Relatives with bilateral breast cancer or both breast and ovarian cancers<\/li><li>Known BRCA1 or BRCA2 mutations in the family<\/li><\/ul><p><strong><br \/>Preventive Measures and Management<\/strong><\/p><p>For individuals who test BRCA-positive, several strategies can reduce cancer risk:<\/p><ul><li>Enhanced Surveillance: Regular screenings like mammograms and MRIs, beginning at a younger age<\/li><li>Preventive procedures such as bilateral prophylactic mastectomies and bilateral salpingo-oophorectomies (removal of the ovaries and fallopian tubes) can dramatically lower cancer risk<\/li><\/ul><p><br \/>However, it is essential to note that these decisions are best made in consultation with a specialist and tailored to the individual&#8217;s risk profile and personal circumstances.<\/p><p><strong><br \/>Conclusion<\/strong><\/p><p>Understanding hereditary cancer risks &#8211; especially BRCA-related mutations &#8211; is a vital step in proactive health planning. With established, trusted services like NCCS and others, Singaporeans can access the tools and support needed to make informed decisions and protect their long-term well-being.<\/p><p><strong><br \/>Sources<\/strong><br \/><a href=\"http:\/\/HealthXchange.sg\" target=\"_blank\" rel=\"noopener\">HealthXchange.sg \u2013 Genetic Testing: Who Should Get It?<\/a><br \/><a href=\"https:\/\/www.mountelizabeth.com.sg\/tests-treatments\/brca-genetic-testing\" target=\"_blank\" rel=\"noopener\">Mount Elizabeth Hospital \u2013 BRCA Genetic Testing<\/a><br \/><a href=\"https:\/\/www.nccs.com.sg\/patient-care\/specialties-services\/cancer-genetics-service\" target=\"_blank\" rel=\"noopener\">National Cancer Centre Singapore \u2013 Cancer Genetics Service<\/a><br \/><a href=\"https:\/\/time.com\/3450368\/the-angelina-effect\/\" target=\"_blank\" rel=\"noopener\">TIME \u2013 The Angelina Effect<\/a><\/p><p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u4e86\u89e3\u9057\u4f20\u6027\u764c\u75c7\u4e0eBRCA\u57fa\u56e0\u68c0\u6d4b\u5728\u65b0\u52a0\u5761\u7684\u5e94\u7528 2013\u5e74\uff0c\u8457\u540d\u597d\u83b1\u575e\u5973\u6f14\u5458\u5b89\u5409\u4e3d\u5a1c\u00b7\u6731\u8389\uff08Angelina  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":412,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-419","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Genetic (BRCA1&amp;2) Screening Test Singapore | The Cancer Centre<\/title>\n<meta name=\"description\" content=\"Genetic screening detects the hereditary cancer occurrence associated with the inherited gene (BRCA). 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